HQL seeks to partner its programs, enabling HQL to focus on its competitive advantage in drug discovery.

HQL Projects

Protein–protein interactions (PPIs) are central to most biological processes, and represent a large and attractive class of targets for therapeutic intervention.  These targets cover a broad range of therapeutic areas with high unmet medical need, and HQL is currently pursing two PPI inhibitor programs in the field of oncology.
Both projects are aimed at apoptosis-regulating pathways.

Bcl-2 family of proteins

Bcl-2Plays a major role in the regulation of apoptosis. This family consists of pro-apoptotic and anti-apoptotic members, whose interactions govern apoptosis.

Many cancer cells overexpress at least one of the anti-apoptotic members of this family, rendering them resistant to chemotherapeutic agents. Therefore these proteins are important targets for the development of new anti-cancer drugs.


 

IAP family of proteins

IAPA second major control point in the execution of apoptosis. . IAP proteins (Inhibitors of Apoptotic Proteins), as their name implies, confer protection from cell death. Overexpression of IAPs has also been documented in various cancer cells.

A natural IAP inhibitor, SMAC, promotes apoptosis. Small molecule mimetics of SMAC can potentially promote apoptosis. of cancer cells overexpressing both IAPs and Bcl-2 family anti-apoptotic proteins.


 

PCSK9

3BPS fragments selected liked Min2

PCSK9 - Plays a critical role in LDLR degradation.

Inhibition of PCSK9 leads to increase in LDLR and concomitant decrease in circulating LDL cholesterol.
In the U.S. 63 million people (20%) have an elevated LDLc.
>60% do not reach LDLc lowering goal with statins.




Pipeline

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